The landmark COBRRA (Comparison of Bleeding Risk between Rivaroxaban and Apixaban for acute VTE) trial has been published in the New England Journal of Medicine today.
This open-label study, conducted across 32 sites in Australia, Canada, and Ireland, was designed to address a significant clinical gap: the absence of head-to-head trials between direct oral anticoagulants (DOACs) that has previously prevented clinical guidelines from recommending a specific drug for acute VTE.
THANZ was a critical partner in this landmark international collaboration. This achievement would not have been possible without the dedication of our lead partners, the Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network and the International Network of Venous Thromboembolism Clinical Research Networks (INVENT). We extend our deepest gratitude to them for their shared vision and leadership.
Locally, we extend a special and profound thanks to our Australian lead and fellow THANZ member, A/Prof Vivien Chen. Vivien’s successful Medical Research Future Fund (MRFF) grant application was the catalyst that enabled the vital participation of our Australian sites.
The success of the COBRRA trial highlights the amazing work we can accomplish as a united thrombosis and haemostasis community. It is a powerful testament to what we can achieve when we pool our expertise, resources, and passion across borders to directly improve patient outcomes.
Please join THANZ in congratulating A/Prof Chen and everyone involved in bringing this vital research to fruition!!!
| Site | Name | Affiliation |
| Orange Health Service | Douglas Lenton | Central West Cancer Centre, Orange Hospital, NSW, Australia. |
| Royal North Shore Hospital | Christopher Ward | Dept of Haematology, Royal North Shore Hospital Kolling Institute, University of Sydney |
| Hunter Clot Clinic | Ritam Prasad | Haematologist , Hunter Clot Clinic, NSW Health Pathology, Calvary Mater Newcastle, New South Wales, Australia |
| Liverpool Hospital | Sara Ng | Department of Haematology, Liverpool Hospital, NSW Australia University of New South Wales, NSW, Australia |
| Royal Prince Alfred Hospital | Freda H Passam | Haematology Dept, Royal Prince Alfred Hospital Camperdown, New South Wales, Australia |
| Launceston General Hospital | Ming Sheng Lim | Affiliation Department of Haematology, Launceston General Hospital, Launceston Tasmania, Australia. |
| Monash Medical Centre | Ashwini Bennett | 1. Haematology Department, Monash Health, Victoria, Australia 2. Monash University, Victoria, Australia |
| Blacktown Hospital | Helen J Crowther | Department of Haematology, Blacktown Hospital, NSW, Australia |
| Tweed Hospital | Sunelle Engelbrecht | Tweed Valley Hospital, NSW Australia. |
| Concord Repatriation General Hospital | Camille Durivage | Department of Haematology, Concord Repatriation and General Hospital, Sydney, Australia and Department of Internal Medicine, Maisonneuve-Rosemont Hospital, Montreal, Canada. |
| Austin Hospital | Abbey Willcox | 1) Austin Hospital, Department of Haematology, Melbourne Australia 2) Alfred Hospital, Department of Haematology, Melbourne Australia 3) Australian Centre for Blood Diseases, Monash University, Melbourne Australia |
| Alfred Hospital | Danielle H Robinson | 1) Alfred Hospital, Department of Haematology, Melbourne Australia 2) Australian Centre for Blood Diseases, Monash University, Melbourne Australia |
| Fiona Stanley Hospital | Dominc Pepperell | Department of Haematology, Fiona Stanley Hospital, Perth, Western Australia |
| Alfred Hospital | Caroline Dix | Department of Clinical Haematology, Alfred hospital, Melbourne. |
| Concord Repatriation General Hospital | Vivien M. Chen | 1. Department of Haematology and ANZAC Research Institute, Concord Repatriation and General Hospital, Sydney Australia 2. Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia. |
| Alfred Hospital | Huyen Tran | Clinical Haematology department, Alfred Hospital; Australian Centre for Blood Diseases, Monash University, Victoria, Australia |
| Westmead Hospital | Jennifer Curnow | 1. Westmead hospital, Western Sydney Local Health District 2. University of Sydney |
| Peninsula Private Hospital | Kay Htun | Peninsula Private Hospital, Victoria, Australia |